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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9365541 B1

PDFFull Text
Date of Patent:
Jun. 14, 2016

Filed:

Oct. 30, 2013

Compounds for use in the treatment of parasitic diseases

Applicants:

Irbm—science Park S.p.a., Pomezia (RM), IT;

C.n.c.c.s. Scarl Collezione Nazionale Dei Composti Chimici E Centro Screening, Pomezia (RM), IT;

Inventors:

Sergio Altamura, Pomezia, IT;

Ilaria Biancofiore, Pomezia, IT;

Alberto Bresciani, Pomezia, IT;

Federica Ferrigno, Pomezia, IT;

Steven Harper, Pomezia, IT;

Ralph Laufer, Pomezia, IT;

Jesus Maria Ontoria Ontoria, Pomezia, IT;

Savina Malancona, Pomezia, IT;

Edith Monteagudo, Pomezia, IT;

Emanuela Nizi, Pomezia, IT;

Maria Vittoria Orsale, Pomezia, IT;

Simona Ponzi, Pomezia, IT;

Giacomo Paonessa, Pomezia, IT;

Vincenzo Summa, Pomezia, IT;

Maria Veneziano, Pomezia, IT;

Assignee:

IRBM—SCIENCE PARK S.P.A., Pomezia (RM), IT;

Attorney:

Lucas & Mercanti, LLP.

Primary Examiner:

D M Seaman

Int. Cl.
CPC ...
C07D 233/64 (2006.01); A61K 31/427 (2006.01); C07D 401/04 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 453/02 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 513/04 (2006.01); A61K 45/06 (2006.01); A61K 31/439 (2006.01); A61K 31/4709 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/427 (2013.01); A61K 31/439 (2013.01); A61K 31/4709 (2013.01); A61K 45/06 (2013.01); C07D 233/64 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 453/02 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.

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