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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9365504 B1

PDFFull Text
Date of Patent:
Jun. 14, 2016

Filed:

Mar. 21, 2011

Salts of kukoamine b, preparation method and use thereof

Applicants:

Jiang Zheng, Chongqing, CN;

Xinchuan Zheng, Chongqing, CN;

Xin Liu, Chongqing, CN;

Hong Zhou, Chongqing, CN;

Ning Wang, Chongqing, CN;

Hongwei Cao, Chongqing, CN;

Yan LI, Chongqing, CN;

Yongling LU, Chongqing, CN;

Kecen Zhao, Chongqing, CN;

Jingcheng Yang, Chongqing, CN;

Yang Yang, Chongqing, CN;

Yuanfeng Zhu, Chongqing, CN;

Guo Wei, Chongqing, CN;

Min Huang, Chongqing, CN;

Inventors:

Jiang Zheng, Chongqing, CN;

Xinchuan Zheng, Chongqing, CN;

Xin Liu, Chongqing, CN;

Hong Zhou, Chongqing, CN;

Ning Wang, Chongqing, CN;

Hongwei Cao, Chongqing, CN;

Yan Li, Chongqing, CN;

Yongling Lu, Chongqing, CN;

Kecen Zhao, Chongqing, CN;

Jingcheng Yang, Chongqing, CN;

Yang Yang, Chongqing, CN;

Yuanfeng Zhu, Chongqing, CN;

Guo Wei, Chongqing, CN;

Min Huang, Chongqing, CN;

Assignees:

THE FIRST AFFILIATED HOSPITAL, THIRD MILITARY UNIVERSITY, PLA, Chongqing, CN;

TIANJIN CHASESUN PHARMACEUTICAL CO., LTD., Tianjin, CN;

Attorney:

Patterson Thuente Pedersen, P.A.

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Chris Simmons

Int. Cl.
CPC ...
C07C 37/02 (2006.01); C07C 235/34 (2006.01); C07C 309/04 (2006.01); C07C 53/08 (2006.01); C07C 55/10 (2006.01); C07C 59/08 (2006.01); C07C 59/245 (2006.01); C07C 59/255 (2006.01); C07C 53/10 (2006.01); C07C 57/145 (2006.01); C07C 229/24 (2006.01); C07C 309/30 (2006.01); C07C 53/122 (2006.01); C07C 53/124 (2006.01); C07C 55/06 (2006.01); C07C 55/08 (2006.01); C07C 55/14 (2006.01); C07C 57/15 (2006.01); C07C 57/44 (2006.01); C07C 59/265 (2006.01); C07C 59/50 (2006.01); C07C 63/06 (2006.01); C07C 309/25 (2006.01);
U.S. Cl.
CPC ...
C07C 309/04 (2013.01); C07C 53/08 (2013.01); C07C 53/10 (2013.01); C07C 53/122 (2013.01); C07C 53/124 (2013.01); C07C 55/06 (2013.01); C07C 55/08 (2013.01); C07C 55/10 (2013.01); C07C 55/14 (2013.01); C07C 57/145 (2013.01); C07C 57/15 (2013.01); C07C 57/44 (2013.01); C07C 59/08 (2013.01); C07C 59/245 (2013.01); C07C 59/255 (2013.01); C07C 59/265 (2013.01); C07C 59/50 (2013.01); C07C 63/06 (2013.01); C07C 229/24 (2013.01); C07C 235/34 (2013.01); C07C 309/25 (2013.01); C07C 309/30 (2013.01);
Abstract

Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.

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