The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 14, 2016

Filed:

Jul. 19, 2012
Applicants:

Paul Edward Floreancig, Pittsburgh, PA (US);

Billy W. Day, Pittsburgh, PA (US);

Shuangyi Wan, Shanghai, CH;

Fanghui Wu, Pittsburgh, PA (US);

Inventors:

Paul Edward Floreancig, Pittsburgh, PA (US);

Billy W. Day, Pittsburgh, PA (US);

Shuangyi Wan, Shanghai, CH;

Fanghui Wu, Pittsburgh, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); C07D 407/06 (2006.01); C07D 407/12 (2006.01); C07D 407/14 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48384 (2013.01); C07D 407/06 (2013.01); C07D 407/12 (2013.01); C07D 407/14 (2013.01);
Abstract

Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold includes a substituent at the C8 and/or C11 positions that may include a linker that may be conjugated to a targeting moiety. The pederin/psymberin chimera scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The pederin, psymberin or pederin/psymberin chimera scaffold may be modified to include substituents at positions other than the C10 or C13 of pederin, or the C8 and C11 of psymberin.


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