The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2016
Filed:
Aug. 13, 2009
Clark Q. Pan, Castro Valley, CA (US);
John E. Murphy, Berkeley, CA (US);
Baisong Mei, Danville, CA (US);
Jonathan S. Strauss, Walnut Creek, CA (US);
Hendri Tjandra, Union City, CA (US);
Jianmin Chen, Concord, CA (US);
Thomas Barnett, Chapel Hill, NC (US);
Liang Tang, Richmond, CA (US);
Deqian Wang, Concord, CA (US);
Clark Q. Pan, Castro Valley, CA (US);
John E. Murphy, Berkeley, CA (US);
Baisong Mei, Danville, CA (US);
Jonathan S. Strauss, Walnut Creek, CA (US);
Hendri Tjandra, Union City, CA (US);
Jianmin Chen, Concord, CA (US);
Thomas Barnett, Chapel Hill, NC (US);
Liang Tang, Richmond, CA (US);
Deqian Wang, Concord, CA (US);
BAYER HEALTHCARE LLC, Whippany, NJ (US);
Abstract
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.