The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9364506 B1

PDF
Full Text
Expired
Date of Patent:
Jun. 14, 2016

Filed:

May. 20, 2014
Applicant:

The J. David Gladstone Institutes, San Francisco, CA (US);

Inventors:

Deepak Srivastava, San Francisco, CA (US);

Kimberly R. Cordes, San Francisco, CA (US);

Assignee:

The J. David Gladstone Institutes, San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 35/34 (2015.01); C12N 5/071 (2010.01); C12N 15/113 (2010.01); C12N 5/077 (2010.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 35/34 (2013.01); C12N 5/0661 (2013.01); C12N 5/0691 (2013.01); C12N 15/113 (2013.01); C12N 15/85 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/32 (2013.01); C12N 2501/65 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2840/007 (2013.01);
Abstract

The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous miR-143 and/or miR-145 nucleic acids; and artificial tissues comprising the genetically modified cells. The present disclosure provides methods and compositions for reducing pathological angiogenesis. The present disclosure provides methods of inducing therapeutic angiogenesis. The present disclosure provides methods, compositions, and devices for inhibiting vascular smooth muscle cell proliferation.


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