The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 14, 2016

Filed:

Jan. 21, 2014
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Qiao Lin, New York, NY (US);

Xian Huang, New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); A61B 5/145 (2006.01); G01N 27/327 (2006.01); G01N 33/543 (2006.01); B01L 3/00 (2006.01); A61B 5/00 (2006.01); G01N 33/66 (2006.01); G01N 27/22 (2006.01);
U.S. Cl.
CPC ...
A61B 5/14532 (2013.01); A61B 5/0015 (2013.01); B01L 3/502753 (2013.01); G01N 27/327 (2013.01); G01N 33/5438 (2013.01); G01N 33/66 (2013.01); B01L 2200/10 (2013.01); B01L 2200/147 (2013.01); B01L 2200/148 (2013.01); B01L 2300/023 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0874 (2013.01); B01L 2300/1822 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0433 (2013.01); G01N 27/226 (2013.01);
Abstract

Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. A microdevice useful for the disclosed techniques includes a semi-permeable membrane structure, a substrate, a first and second microchambers formed between the membrane structure and the substrate. The first microchamber can be adapted to receive a solution including the polymer, and the second microchamber can be adapted to receive a reference solution. Environmental target analyte can permeate the semi-permeable membrane structure and enters the first microchamber and the second microchamber. Based on the difference in a property associated with the polymer solution that is responsive to the target analyte-polymer binding, and the corresponding property associated with reference solution, the presence and/or concentration of the target analyte can be determined.


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