The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Aug. 16, 2007
Applicant:
Michael H. Cardone, Dorchester, MA (US);
Inventor:
Michael H. Cardone, Dorchester, MA (US);
Assignee:
EUTROPICS PHARMACEUTICALS, INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C40B 40/10 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01); A61K 49/00 (2006.01); G01N 33/58 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5079 (2013.01); A61K 49/0004 (2013.01); C40B 40/10 (2013.01); G01N 33/586 (2013.01); G01N 33/53 (2013.01); G01N 33/543 (2013.01); G01N 33/574 (2013.01); G01N 2510/00 (2013.01);
Abstract
The invention is an assay designed to identify agents that modulate apoptosis. The invention provides an assay system and methods for screening for inhibitors of the Bcl-2 family of proteins. In various aspects the invention provides an assay system containing a liposome reagent and an immobilized BH3 domain peptide. In further aspects the invention provides an assay system containing mitochondria, an immobilized BH3 domain peptide and a mitochondrial binding agent, e.g. an anti-VDAC anti-body.