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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9359403 B1

PDFFull Text
Date of Patent:
Jun. 07, 2016

Filed:

Jun. 30, 2014

Activated collagen scaffold materials and their special fused active restoration factors

Applicants:

Yantai Zhenghai Bio-technology Co., Ltd., Shandong, CN;

Institute of Genetics and Developmental Biology Chinese Academy of Science, Beijing, CN;

Inventors:

Jianwu Dai, Beijing, CN;

Bing Chen, Beijing, CN;

Hang Lin, Beijing, CN;

Wenjie Sun, Beijing, CN;

Wenxue Zhao, Beijing, CN;

Assignee:

YANTAI ZHENGHAI BIO-TECH CO., LTD, Yantai, Shandong, CN;

Attorney:

Knobbe, Martens, Olson & Bear, LLP

Primary Examiner:

Alexander Kim

Int. Cl.
CPC ...
C07K 7/06 (2006.01); A61L 27/22 (2006.01); A61L 27/24 (2006.01); C07K 14/48 (2006.01); C07K 14/485 (2006.01); C07K 14/49 (2006.01); C07K 14/50 (2006.01); C07K 14/51 (2006.01); C07K 14/52 (2006.01); C07K 14/78 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); A61L 27/227 (2013.01); A61L 27/24 (2013.01); C07K 14/48 (2013.01); C07K 14/485 (2013.01); C07K 14/49 (2013.01); C07K 14/503 (2013.01); C07K 14/51 (2013.01); C07K 14/52 (2013.01); C07K 14/78 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/21 (2013.01);
Abstract

Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:12 at N-terminus.

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