The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Jul. 10, 2014
Applicant:
Tokai Pharmaceuticals, Inc., Cambridge, MA (US);
Inventor:
David S. Casebier, Carlisle, MA (US);
Assignee:
Tokai Pharmaceuticals, Inc., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07J 43/00 (2006.01); A61K 31/58 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
C07J 43/003 (2013.01); A61K 31/58 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01);
Abstract
Prodrugs of C-17-heterocyclic-steroidal drugs providing improved oral bioavailability and phamacokinetics are described. The drugs are inhibitors of human CYP 17 enzyme, as well as potent antagonists of both wild type and mutant androgen receptors (AR), and are useful for the treatment of urogenital and/or androgen-related cancers, diseases and/or conditions, such as human prostate cancer, breast cancer, and prostate hyperplasia. The disclosure describes methods of synthesizing and using the prodrugs in cancer therapy.