The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Jul. 31, 2014
Beta Pharma, Inc., Princeton, NJ (US);
Yinxiang Wang, Cheshire, CT (US);
Guojian Xie, Cheshire, CT (US);
Lieming Ding, Hangzhou, CN;
Fenlai Tan, Troy, MI (US);
Yunyan Hu, Beijing, CN;
Wei He, Beijing, CN;
Bin Han, Beijing, CN;
Wei Long, Beijing, CN;
Yong Liu, Beijing, CN;
Haima Ai, Beijing, CN;
Charles Davis, Germantown, WI (US);
Don Zhang, Plainsboro, NJ (US);
Beta Pharma, Inc., Princeton, NJ (US);
Abstract
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.