The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 07, 2016

Filed:

Nov. 20, 2012
Applicant:

Suzanne Grimshaw, Poway, CA (US);

Inventors:

Dennis A. Carson, La Jolla, CA (US);

Kenji Takabayashi, Poway, CA (US);

Howard B. Cottam, Escondido, CA (US);

Michael Chan, San Diego, CA (US);

Christina C. N. Wu, Escondido, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/52 (2006.01); A61K 31/7076 (2006.01); C12P 19/40 (2006.01); C07D 473/16 (2006.01); C07D 473/34 (2006.01); C07D 473/18 (2006.01); C07D 473/24 (2006.01);
U.S. Cl.
CPC ...
C07D 473/16 (2013.01); C07D 473/18 (2013.01); C07D 473/24 (2013.01); C07D 473/34 (2013.01);
Abstract

The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.


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