The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Jun. 24, 2013
Applicant:
Crown Bioscience Inc. (Taiwan), Taipei, TW;
Inventors:
Deyi Zhang, Taicang, CN;
Ruihao Zhang, Taicang, CN;
Boyu Zhong, Taicang, CN;
Chuan Shih, Taicang, CN;
Assignee:
CROWN BIOSCIENCE INC. (Taiwan), Xinyi Dist. Taipei, TW;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); A61K 31/4427 (2006.01); C07D 413/12 (2006.01); A61K 31/44 (2006.01); C07D 403/12 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); C07D 213/75 (2006.01); C07D 239/47 (2006.01); C07D 213/68 (2006.01); C07D 213/72 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 413/12 (2013.01); A61K 31/44 (2013.01); A61K 31/4427 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); C07D 213/68 (2013.01); C07D 213/72 (2013.01); C07D 213/75 (2013.01); C07D 239/47 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01);
Abstract
Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.