The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Jul. 21, 2015
Applicant:
F.i.s.—fabbrica Italiana Sintetici S.p.a., Montecchio Maggiore-Vicenza, IT;
Inventors:
Francesco Fontana, Longone al Segrino, IT;
Alfredo Paio, Legnago, IT;
Assignee:
F.I.S.—Fabbrica Italiana Sintetiei, Montecchio Maggiore, IT;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 405/04 (2006.01); C07C 309/30 (2006.01);
U.S. Cl.
CPC ...
C07D 405/04 (2013.01); C07C 309/30 (2013.01); C07D 405/14 (2013.01);
Abstract
The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.