The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Feb. 07, 2014
Applicant:
Nanooncology, Inc., Madison, WI (US);
Inventors:
Assignee:
NanoOncology, Inc., Madison, WI (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07K 14/78 (2006.01); C12N 15/87 (2006.01); A61K 38/02 (2006.01); A61K 39/44 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/48853 (2013.01); A61K 38/02 (2013.01); A61K 39/44 (2013.01); A61K 47/48292 (2013.01); A61K 47/48884 (2013.01); A61K 48/0041 (2013.01); C07K 14/78 (2013.01); C12N 15/113 (2013.01); C12N 15/87 (2013.01); C07K 2319/035 (2013.01); C07K 2319/85 (2013.01); C12N 2810/856 (2013.01);
Abstract
This invention describes a protein nanoparticle system for targeting siRNA or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the siRNA. Specific targeting peptides are fused to the core ELP structure by standard genetic engineering techniques. These targeting peptides confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.