The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Mar. 25, 2015
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Susan K. Heimbecher, Morris Plains, NJ (US);
David Monteith, Pittstown, NJ (US);
James D. Pipkin, Lawrence, KS (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 47/40 (2006.01); A61K 31/496 (2006.01); A61K 31/724 (2006.01);
U.S. Cl.
CPC ...
A61K 47/40 (2013.01); A61K 9/0019 (2013.01); A61K 31/496 (2013.01); A61K 31/724 (2013.01);
Abstract
The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified β-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.