The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
Nov. 01, 2013
Thomas P. Loughran, Jr., Hummelstown, PA (US);
Ravi Kothapalli, Wesley Chapel, FL (US);
Thomas P. Loughran, Jr., Hummelstown, PA (US);
Ravi Kothapalli, Wesley Chapel, FL (US);
University of South Florida, Tampa, FL (US);
Abstract
Methods of diagnosing large granular lymphocytic leukemia are provided herein. Novel splice variants of Granzyme B and Granzyme H as well as methods for screening for compositions regulating the splice variants and the development of therapeutic agents for the modulation thereof are also provided herein. Regulation of the splice variants is useful in the treatment of leukemic LGL, where these isoforms are constitutively over-expressed.
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