The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
May. 02, 2012
Michelle L. Hastings, North Chicago, IL (US);
Frank Rigo, Carlsbad, CA (US);
C. Frank Bennett, Carlsbad, CA (US);
Michelle L. Hastings, North Chicago, IL (US);
Frank Rigo, Carlsbad, CA (US);
C. Frank Bennett, Carlsbad, CA (US);
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Rosalind Franklin University of Medicine and Science, North Chicago, IL (US);
Abstract
The present invention provides compounds comprising oligonucleotides complementary to an Usher transcript. Certain such compounds are useful for hybridizing to an Usher transcript, including but not limited, to an Usher transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the Usher transcript. In certain such embodiments, the Usher transcript includes a mutation that results in cryptic splicing and hybridization of the oligonucleotide results in a decrease in the amount of cryptic splicing. In certain embodiments, such compounds are used to treat Usher Syndrome.