The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
Jun. 21, 2014
Applicant:
University of Notre Dame Du Lac, Notre Dame, IN (US);
Inventor:
Bradley Smith, Granger, IN (US);
Assignee:
University of Notre Dame du Lac, Notre Dame, IN (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 409/14 (2006.01); C07D 409/08 (2006.01);
U.S. Cl.
CPC ...
C07D 409/14 (2013.01); C07D 409/08 (2013.01);
Abstract
The present disclosure provides compositions and methods for the synthesis and use of croconaine compounds. The disclosed compounds are easily prepared from croconic acid. A halothiophene is reacted with an alkanolamine, the resulting aminothiophene is modified by appending a desired functional group to the hydroxyl group, and the modified aminothiophene is reacted with croconic acid to form the final compound. Applications of such croconaine compounds include photothermal imaging, photothermal therapy, light-activated drug release, and tissue welding.