The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
May. 16, 2012
Fuli Zhang, Shanghai, CN;
Zhezhou Yang, Shanghai, CN;
Chunbo Yang, Shanghai, CN;
Daoxin Chen, Zhejiang, CN;
Zhiqing Yang, Zhejiang, CN;
Rentong Sun, Zhejiang, CN;
Hua Bai, Zhejiang, CN;
Fuli Zhang, Shanghai, CN;
Zhezhou Yang, Shanghai, CN;
Chunbo Yang, Shanghai, CN;
Daoxin Chen, Zhejiang, CN;
Zhiqing Yang, Zhejiang, CN;
Rentong Sun, Zhejiang, CN;
Hua Bai, Zhejiang, CN;
Zhejiang Hisun Pharmaceutical Co., Ltd., Zhejiang, CN;
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Abstract
The present invention provides a preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate, preparation methods for intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, as well as a method for using (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium to prepare rivastigmine which can be used for the treatment of Alzheimer's disease.