The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
Feb. 06, 2012
Applicants:
Taeghwan Hyeon, Seoul, KR;
Yuanzhe Piao, Suwon-si, KR;
Yong IL Park, Seoul, KR;
Inventors:
Assignee:
HANWHA CHEMICAL CORPORATION, , KR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/055 (2006.01); B05D 3/00 (2006.01); A61K 49/18 (2006.01); C01G 49/02 (2006.01); C09C 1/24 (2006.01); B82Y 30/00 (2011.01); C09C 3/08 (2006.01);
U.S. Cl.
CPC ...
A61K 49/1824 (2013.01); A61K 49/186 (2013.01); A61K 49/1863 (2013.01); B82Y 30/00 (2013.01); C01G 49/02 (2013.01); C09C 1/24 (2013.01); C01P 2002/72 (2013.01); C01P 2004/03 (2013.01); C01P 2004/04 (2013.01); C01P 2004/51 (2013.01); C01P 2004/64 (2013.01); C01P 2006/42 (2013.01); C09C 3/08 (2013.01);
Abstract
The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.