The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
Dec. 29, 2011
Chris Mcguigan, Cardiff, GB;
Karolina Madela, Cardiff, GB;
Claire Bourdin, Cardiff, GB;
John Vernachio, Canton, GA (US);
Stanley Chamberlain, Chapel Hill, NC (US);
Chris McGuigan, Cardiff, GB;
Karolina Madela, Cardiff, GB;
Claire Bourdin, Cardiff, GB;
John Vernachio, Canton, GA (US);
Stanley Chamberlain, Chapel Hill, NC (US);
INHIBITEX, INC., Alpharetta, GA (US);
UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED, Cardiff, GB;
Abstract
This invention is directed to phosphoroamidate and phosphorodiamidate derivatives including the compounds of formula (I) having the structure wherein U, V, W, Z, R, X, X, and Y are defined herein. These compounds and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals infected by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV). The compounds of this invention may be prepared by various methods known in the art of organic chemistry in general and nucleoside and nucleotide analog synthesis in particular.