The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
Mar. 07, 2014
Wyeth Holdings Llc, Madison, NJ (US);
Arthur Kunz, New City, NY (US);
Justin Keith Moran, Valley Cottage, NY (US);
Joseph Thomas Rubino, Towaco, NJ (US);
Neera Jain, New City, NY (US);
Eugene Joseph Vidunas, Middletown, NY (US);
John McLean Simpson, Upper Nyack, NY (US);
Nishith Merchant, Palisades Park, NJ (US);
John Francis DiJoseph, Woodbridge, NJ (US);
Mark Edward Ruppen, Garnerville, NY (US);
Nitin Krishnaji Damle, Upper Saddle River, NJ (US);
Paul David Robbins, Derwood, MD (US);
Andrew George Popplewell, Staines, GB;
WYETH HOLDINGS LLC, Madison, NJ (US);
Abstract
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.