The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 31, 2016

Filed:

Sep. 09, 2013
Applicants:

Rega Foundation, Leuven, BE;

University College Cardiff Consultants Limited, Cardiff, GB;

Inventors:

Christopher McGuigan, Cardiff, GB;

Jan Balzarini, Heverlee, BE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/14 (2006.01); C07D 498/04 (2006.01); C07D 487/04 (2006.01); A61K 31/498 (2006.01); C07D 491/04 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); A61K 31/4985 (2006.01); A61K 31/706 (2006.01); C07D 403/02 (2006.01); C07D 405/04 (2006.01); C07H 19/23 (2006.01); C07H 19/24 (2006.01);
U.S. Cl.
CPC ...
A61K 31/498 (2013.01); A61K 31/4985 (2013.01); A61K 31/706 (2013.01); C07D 403/02 (2013.01); C07D 405/04 (2013.01); C07D 487/04 (2013.01); C07D 491/04 (2013.01); C07D 498/04 (2013.01); C07H 19/06 (2013.01); C07H 19/10 (2013.01); C07H 19/14 (2013.01); C07H 19/23 (2013.01); C07H 19/24 (2013.01);
Abstract

A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; Rand Rcan be hydrogen, alkyl, cycloalkyl, halogen, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, or aryl; Q can be O, S or CY, where Y may be H, alkyl or halogen; X can be O, NH, S, N-alkyl, (CHR)where m is 1 to 10, and CY; Z can be O, S, NH, or N-alkyl; U″ is H and U' can be H or CH; wherein: T can be OH, H, halogen, O-alkyl, O-acyl, O-aryl, CN, NHor N; T′ and T″ can be H or halogen; and W can be H or a phosphate group. Compounds show anti-viral activity, for example with respect to varicella zoster virus.


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