The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 31, 2016

Filed:

Dec. 16, 2011
Applicants:

Gerald W. Shipps, Jr., Stoneham, MA (US);

Xiaohua Huang, Brookline, MA (US);

Yongqi Deng, Newton, MA (US);

Liang Zhu, Waltham, MA (US);

Alan B. Cooper, West Caldwell, NJ (US);

Binyuan Sun, Chestnut Hill, MA (US);

Abdelghani Achab, Melrose, MA (US);

Sie-mun Lo, Springfield, VA (US);

Inventors:

Gerald W. Shipps, Jr., Stoneham, MA (US);

Xiaohua Huang, Brookline, MA (US);

Yongqi Deng, Newton, MA (US);

Liang Zhu, Waltham, MA (US);

Alan B. Cooper, West Caldwell, NJ (US);

Binyuan Sun, Chestnut Hill, MA (US);

Abdelghani Achab, Melrose, MA (US);

Sie-Mun Lo, Springfield, VA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/56 (2006.01); C07D 401/04 (2006.01); C07D 471/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 417/04 (2006.01); A61K 31/416 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/416 (2013.01); A61K 31/437 (2013.01); A61K 45/06 (2013.01); C07D 231/56 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R, R, R, m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.


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