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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9351954 B1

PDFFull Text
Date of Patent:
May. 31, 2016

Filed:

Mar. 12, 2014

Multicyclic compounds and methods of use thereof

Applicants:

Sunovion Pharmaceuticals Inc., Marlborough, MA (US);

Pgi Drug Discovery Llc., Tarrytown, NY (US);

Inventors:

Liming Shao, Lincoln, MA (US);

John Emmerson Campbell, Cambridge, MA (US);

Michael Charles Hewitt, Somerville, MA (US);

Una Campbell, Marlborough, MA (US);

Taleen G. Hanania, Valhalla, NY (US);

Assignees:

Sunovion Pharmaceuticals Inc., Marlborough, MA (US);

PGI Drug Discovery LLC., Tarrytown, NY (US);

Attorney:

Wilmer Cutler Pickering Hale and Dorr LLP

Primary Examiner:

Rita Desai

Assistant Examiner:

Ben S Michelson

Int. Cl.
CPC ...
C07D 495/02 (2006.01); C07D 233/00 (2006.01); C07D 403/02 (2006.01); C07D 403/14 (2006.01); C07D 231/00 (2006.01); C07D 487/00 (2006.01); C07D 487/02 (2006.01); C07D 405/00 (2006.01); C07D 409/00 (2006.01); C07D 411/00 (2006.01); A61K 31/415 (2006.01); A61K 31/40 (2006.01); A61K 31/48 (2006.01); A61K 31/381 (2006.01); C07D 277/60 (2006.01); C07D 333/54 (2006.01); C07D 333/76 (2006.01); C07D 333/78 (2006.01); C07D 495/04 (2006.01); C07D 495/20 (2006.01); A61K 31/435 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/381 (2013.01); A61K 31/435 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 277/60 (2013.01); C07D 333/54 (2013.01); C07D 333/76 (2013.01); C07D 333/78 (2013.01); C07D 495/04 (2013.01); C07D 495/20 (2013.01);
Abstract

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

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