The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2016
Filed:
Jun. 07, 2013
City of Hope, Duarte, CA (US);
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Ravi Bhatia, Arcadia, CA (US);
Smita Bhatia, Arcadia, CA (US);
Stephen Forman, Duarte, CA (US);
Jerald P. Radich, Seattle, WA (US);
Liang Li, Duarte, CA (US);
Min Li, Duarte, CA (US);
Lue Ping Zhao, Seattle, WA (US);
CITY OF HOPE, Duarte, CA (US);
FRED HUTCHINSON CANCER RESEARCH CENTER, Seattle, WA (US);
Abstract
In one embodiment, a gene expression signature for predicting risk of developing therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) after autologous hematopoietic cell transplantation (aHCT) is provided. In another embodiment, a method for predicting a risk for development of t-MDS/AML after aHCT is provided. Such a method may include providing a biological sample that contains CD34 cells from a subject; detecting a test expression level of a set of two or more genes of a gene expression signature; comparing the test expression level of a set of corresponding training expression levels that include a training case expression level and a training control expression level; and predicting a high risk of developing t-MDS/AML when the test expression level is at or about the training case expression level or predicting a low risk of developing t-MDS/AML when the test expression level is at or about the training control expression level.