The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2016
Filed:
Jun. 26, 2009
Marie-annick Buendia, Le Perreux sur Marne, FR;
Carolina Armengol Niell, Blanes, ES;
Stefano Cairo, Longpont-sur-Orge, FR;
Aurélien DE Reynies, Paris, FR;
Marie-Annick Buendia, Le Perreux sur Marne, FR;
Carolina Armengol Niell, Blanes, ES;
Stefano Cairo, Longpont-sur-Orge, FR;
Aurélien de Reynies, Paris, FR;
Institut Pasteur, Paris, FR;
Institut National de la Santé et de la Recherche Médicale, Paris, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Abstract
The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method enables to determine the grade of the liver tumor, such as hepatoblastoma (HB) or a hepatocellular carcinoma (HCC). The invention is also directed to kits comprising a plurality of pairs of primers or a plurality of probes specific for a set of genes, as well as to solid support or composition comprising a set of probes specific for a set of genes. These methods are useful to determine the grade of a liver tumor in a sample obtained from a patient, to determine the risk of developing metastasis and/or to define the therapeutic regimen to apply to a patient.