The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2016

Filed:

Mar. 19, 2014
Applicant:

The J. David Gladstone Institutes, San Francisco, CA (US);

Inventors:

Li Gan, Burlingame, CA (US);

Lennart Mucke, San Francisco, CA (US);

Assignee:

The J. David Gladstone Institutes, San Francisco, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); C12Q 1/37 (2006.01); A61K 38/55 (2006.01); C07K 16/38 (2006.01); C12N 15/113 (2010.01); G01N 33/68 (2006.01); A61K 31/7052 (2006.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); A61K 31/7052 (2013.01); A61K 38/00 (2013.01); A61K 38/55 (2013.01); A61K 39/3955 (2013.01); C07K 16/38 (2013.01); C12N 15/1136 (2013.01); C12N 15/1137 (2013.01); C12Q 1/68 (2013.01); G01N 33/6896 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2330/51 (2013.01);
Abstract

The present invention provides methods for reducing the level of amyloid beta protein in a cell or tissue, the methods generally involving contacting the cell or tissue with an agent that reduces cystatin C levels and/or activity. The present invention provides methods for treating Alzheimer's disease (AD), and methods for treating cerebral angiopathy, in an individual, the methods generally involving administering to an individual having AD a therapeutically effective amount of an agent that reduces cystatin C levels and/or activity. The present invention further provides methods for identifying an agent that reduces cystatin C levels and/or activity.


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