The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2016
Filed:
Aug. 26, 2011
Applicants:
Keitaro Umezawa, Tokyo, JP;
Lukinavicius Grazvydas, Renens, CH;
Kai Johnsson, Neuchatel, CH;
Inventors:
Assignee:
École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C09B 11/24 (2006.01); C07F 7/08 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
C09B 11/24 (2013.01); C07F 7/081 (2013.01); G01N 33/582 (2013.01);
Abstract
The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formula or its corresponding spirolactone wherein The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows minimal background binding to biomolecules and biomolecular structures.