The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2016
Filed:
Feb. 29, 2012
Andrés Avelino Trabanco-suárez, Toledo, ES;
Henricus Jacobus Maria Gijsen, Beerse, BE;
Michiel Luc Maria Van Gool, Toledo, ES;
Juan Antonio Vega Ramiro, Toledo, ES;
Francisca Delgado-jiménez, Toledo, ES;
Andrés Avelino Trabanco-Suárez, Toledo, ES;
Henricus Jacobus Maria Gijsen, Beerse, BE;
Michiel Luc Maria Van Gool, Toledo, ES;
Juan Antonio Vega Ramiro, Toledo, ES;
Francisca Delgado-Jiménez, Toledo, ES;
JANSSEN PHARMACEUTICA NV, , BE;
Abstract
The present invention relates to novel 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.