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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9346738 B1

PDFFull Text
Date of Patent:
May. 24, 2016

Filed:

May. 22, 2013

Process for the preparation of treprostinil and derivatives thereof

Applicant:

Scipharm Sàrl, Luxembourg, LU;

Inventors:

Nareshkumar Jain, Bristol, PA (US);

Michael Kirkup, Bristol, PA (US);

Michael Marella, Bristol, PA (US);

Sanjeevani Ghone, Bristol, PA (US);

Assignee:

SciPharm SaRL, Luxembourg, LU;

Attorneys:

Loza & Loza, LLP

Michael Fedrick

Primary Examiner:

Pancham Bakshi

Int. Cl.
CPC ...
C07C 59/115 (2006.01); C07C 51/377 (2006.01); C07C 47/565 (2006.01); C07C 47/575 (2006.01); C07F 7/18 (2006.01); C07C 59/72 (2006.01); C12P 31/00 (2006.01); C12P 41/00 (2006.01);
U.S. Cl.
CPC ...
C07C 51/377 (2013.01); C07C 47/565 (2013.01); C07C 47/575 (2013.01); C07C 59/72 (2013.01); C07F 7/18 (2013.01); C07F 7/1844 (2013.01); C07F 7/1852 (2013.01); C07F 7/1892 (2013.01); C12P 31/00 (2013.01); C12P 41/002 (2013.01); C12P 41/004 (2013.01); C07C 2103/14 (2013.01);
Abstract

A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo substituent in 2-position.

Find Patent Forward Citations

Jain, Nareshkumar. (2016). Process for the preparation of treprostinil and derivatives thereof (U.S. Patent No. 9346738). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9346738

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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