The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2016
Filed:
Feb. 06, 2012
Applicants:
Alfonso Gonzalez, Santiago, CL;
Andrea Soza, Santiago, CL;
Claudia Metz, Santiago, CL;
Inventors:
Assignee:
PONTIFICA UNIVERSIDAD CATOLICA DE CHILE, Santiago, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/138 (2006.01); A61K 31/55 (2006.01); A61K 31/133 (2006.01); A61K 31/366 (2006.01); A61K 31/5415 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/55 (2013.01); A61K 31/133 (2013.01); A61K 31/138 (2013.01); A61K 31/366 (2013.01); A61K 31/5415 (2013.01); A61K 45/06 (2013.01);
Abstract
Compounds and combinations of them that inhibit phosphatidic phosphohydrolase (PAP) enzymatic activity are formulated into pharmaceuticals useful in cancer treatment. Inhibitors of PAP can be used for blocking the progression of cancers that depend on the epidermal growth factor receptor (EGFR), its oncogenic variants and other members of its ErbB tyrosine kinase receptor family, through induction of their endocytosis, thus making them inaccessible to the extracellular stimuli that promote maintenance and progression of cancer.