The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2016
Filed:
Mar. 14, 2014
Washington University, St. Louis, MO (US);
The Research Foundation for the State University of New York, Albany, NY (US);
Curators of the University of Missouri, Columbia, MO (US);
Jianmin Cui, Chesterfield, MO (US);
Ira S. Cohen, Stony Brook, NY (US);
Xiaoqin Zou, Columbia, MO (US);
Washington University, St. Louis, MO (US);
The Research Foundation for The State University of New York, Albany, NY (US);
Curators of the University of Missouri, Columbia, MO (US);
Abstract
The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with epilepsy, deafness and arrhythmias including but not limited to, Long-QT syndrome ('LQTS'), and atrial fibrillation. The present disclosure also relates to the discovery of certain regions of KCNQ channels that interact with various channel stimulating molecules such as, ATP, and PIP, as well as KCNQ channel domains that effect voltage dependant channel activation. The disclosure is also directed to the use of small molecules to modulate KCNQ channel activity in a cell. Moreover, the present disclosure relates to the therapeutic effects of treating a subject with modulators of KCNQ channel activity.