The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2016

Filed:

Mar. 16, 2010
Applicants:

Wouter DE Graaff, Oss, NL;

Raymond Zeeman, Oss, NL;

Niels Honcoop, Oss, NL;

Inventors:

Wouter De Graaff, Oss, NL;

Raymond Zeeman, Oss, NL;

Niels Honcoop, Oss, NL;

Assignee:

Intervet Inc., Madison, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/35 (2006.01); A61K 31/365 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/24 (2006.01);
U.S. Cl.
CPC ...
A61K 31/365 (2013.01); A61K 9/0024 (2013.01); A61K 9/209 (2013.01); A61K 9/2027 (2013.01);
Abstract

Disclosed is a drug delivery system from which a macrocyclic lactone can be released with a desirable zero order release profile. The system is based on the use of thermoplastic polymers, and particularly of polyethylene vinyl acetate copolymers (EVA). The drug delivery system of the invention comprises a solid non-porous reservoir in which the macrocyclic lactone is contained, preferably in a concentration well above the saturation concentration, and a non-porous skin covering the reservoir not initially loaded with the drug. The system is preferably in the form of a rod, wherein the core and the skin are concentric, and the end surfaces of the rod are not skin-covered.


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