The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2016
Filed:
Aug. 28, 2006
Richard Jove, Tampa, FL (US);
William Dalton, Tampa, FL (US);
Said Sebti, Tampa, FL (US);
Hua Yu, Tampa, FL (US);
Richard Heller, Temple Terrace, FL (US);
Mark Jaroszeski, Tampa, FL (US);
Richard A. Gilbert, Tampa, FL (US);
Andrew D. Hamilton, Guilford, CT (US);
Richard Jove, Tampa, FL (US);
William Dalton, Tampa, FL (US);
Said Sebti, Tampa, FL (US);
Hua Yu, Tampa, FL (US);
Richard Heller, Temple Terrace, FL (US);
Mark Jaroszeski, Tampa, FL (US);
Richard A. Gilbert, Tampa, FL (US);
Andrew D. Hamilton, Guilford, CT (US);
University of South Florida, Tampa, FL (US);
Yale University, New Haven, CT (US);
Abstract
Signal Transducer and Activator of Transcription (STAT) proteins have a fundamental role cell signaling, and are activated by a large number of cytokines and growth factors. One member of the STAT family, STAT3, has a critical role in oncogenesis. The present invention relates generally to disruption of the pathway of STAT3 signaling in the treatment of human cancer. STAT3 activation is shown to be present in diverse tumor cell lines and tumors, to promote oncogenesis, to inhibit apoptosis, and to reduce sensitivity to chemotherapeutic agents. Inhibition of STAT3 signaling induces apoptosis specifically in tumor cell lines, and increases sensitivity to chemotherapeutic agents. The invention relates more particularly to methods, compositions, means of administering such compositions, and means for identifying such compositions for the inhibition of STAT3 intracellular signaling in the treatment of human cancers.