The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2016

Filed:

Sep. 08, 2010
Applicants:

Christian Baumann, Darmstadt, DE;

Stefan Kienle, Frankfurt am Main, DE;

Karsten Kuhn, Frankfurt am Main, DE;

Harald Legner, Frankfurt am Main, DE;

Inventors:

Christian Baumann, Darmstadt, DE;

Stefan Kienle, Frankfurt am Main, DE;

Karsten Kuhn, Frankfurt am Main, DE;

Harald Legner, Frankfurt am Main, DE;

Assignee:

ELECTROPHORETICS LIMITED, Cobham Surrey, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C40B 30/10 (2006.01); C40B 40/04 (2006.01); C07D 401/12 (2006.01); G01N 33/74 (2006.01); C07B 59/00 (2006.01); C07D 211/14 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
G01N 33/743 (2013.01); C07B 59/002 (2013.01); C07D 211/14 (2013.01); C07D 401/12 (2013.01); G01N 33/58 (2013.01); G01N 2458/15 (2013.01); G01N 2560/00 (2013.01); Y10T 436/196666 (2015.01); Y10T 436/200833 (2015.01); Y10T 436/24 (2015.01);
Abstract

A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure:X-L-M-S—Rewherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: wherein J is C═O, K is NH, and n is 2 or J and K are both CHand n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.


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