The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Jun. 11, 2014
Applicants:
Kyle Gee, Springfield, OR (US);
Vladimir Martin, Eugene, OR (US);
Inventors:
Kyle Gee, Springfield, OR (US);
Vladimir Martin, Eugene, OR (US);
Assignee:
Life Technologies Corporation, Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/353 (2006.01); C07D 311/90 (2006.01); C07D 413/04 (2006.01); C07D 491/04 (2006.01); G01N 33/84 (2006.01); C07D 413/10 (2006.01); C07D 491/147 (2006.01); C09B 11/24 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/582 (2013.01); A61K 31/353 (2013.01); C07D 311/90 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 491/04 (2013.01); C07D 491/147 (2013.01); C09B 11/24 (2013.01); G01N 33/6872 (2013.01); G01N 33/84 (2013.01); G01N 2223/406 (2013.01); G01N 2458/00 (2013.01);
Abstract
Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (M), a reporter molecule and two or more lipophilic groups (G) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups. An exemplary compound for use as a cell permeable metal ion indicator is represented by the structure: