The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Dec. 03, 2009
Michael V. Templin, Bothell, WA (US);
Narendra K. Vaish, Kirkland, WA (US);
Barry A. Polisky, Boulder, CO (US);
Michael E. Houston, Jr., Sammamish, WA (US);
Michael V. Templin, Bothell, WA (US);
Narendra K. Vaish, Kirkland, WA (US);
Barry A. Polisky, Boulder, CO (US);
Michael E. Houston, Jr., Sammamish, WA (US);
Arcturus Therapeutics, Inc., San Diego, CA (US);
Abstract
This disclosure provides double-stranded RNA complexes having one or more hydroxymethyl substituted nucleomonomer(s) in the passenger strand (or sense strand) of an RNA complex. RNA complexes of the disclosure may be useful for therapeutic applications, diagnostic applications or research applications. RNA complexes include short interfering RNA complexes (siRNA) capable of modulating gene expression comprising an antisense strand and a continuous or a discontinuous passenger strand ('sense strand'). Further, one or more hydroxymethyl substituted nucleomonomer(s) of this disclosure may be positioned at the 3'-end, at the 5′-end, at both the 3′-end and 5′end.