The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
May. 14, 2010
Atsuhiko Maeda, Shizuoka, JP;
Hajime Miyamoto, Kanagawa, JP;
Taichi Kuramochi, Shizuoka, JP;
Atsushi Matsuo, Shizuoka, JP;
Tomoyuki Igawa, Shizuoka, JP;
Hirotake Shiraiwa, Shizuoka, JP;
Hiroyuki Tsunoda, Shizuoka, JP;
Tatsuhiko Tachibana, Shizuoka, JP;
Atsuhiko Maeda, Shizuoka, JP;
Hajime Miyamoto, Kanagawa, JP;
Taichi Kuramochi, Shizuoka, JP;
Atsushi Matsuo, Shizuoka, JP;
Tomoyuki Igawa, Shizuoka, JP;
Hirotake Shiraiwa, Shizuoka, JP;
Hiroyuki Tsunoda, Shizuoka, JP;
Tatsuhiko Tachibana, Shizuoka, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
An objective of the present invention is to decrease the immunogenicity of mouse-derived anti-AXL antibodies in humans by humanizing them. The present invention provides antibodies that can bind to a specific region in Anexelekto (AXL) and humanized antibodies that are produced based on such antibodies. The anti-AXL antibodies of the present invention have high antitumor activity, and are useful as agents for decreasing the AXL expression level, antitumor agents, and diagnostic agents for cancer.