The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Jul. 21, 2014
Jun Yuan, Boston, MA (US);
Frederic Zecri, Brookline, MA (US);
Philipp Grosche, Inzlingen, DE;
Hongjuan Zhao, Lexington, MA (US);
Eric Peters, San Diego, CA (US);
Shari Lynn Caplan, Lunenburg, MA (US);
Changgang Lou, Portage, MI (US);
Jun Yuan, Boston, MA (US);
Frederic Zecri, Brookline, MA (US);
Philipp Grosche, Inzlingen, DE;
Hongjuan Zhao, Lexington, MA (US);
Eric Peters, San Diego, CA (US);
Shari Lynn Caplan, Lunenburg, MA (US);
Changgang Lou, Portage, MI (US);
NOVARTIS AG, Basel, CH;
Abstract
The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I' (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.