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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9340579 B1

PDFFull Text
Date of Patent:
May. 17, 2016

Filed:

Nov. 02, 2012

Dpp-4 inhibitor

Applicant:

Nippi, Incorporated, Tokyo, JP;

Inventors:

Osamu Hayashida, Tokyo, JP;

Masashi Kusubata, Tokyo, JP;

Yuji Atsuzawa, Tokyo, JP;

Yuki Taga, Tokyo, JP;

Youichi Koyama, Tokyo, JP;

Shunji Hattori, Tokyo, JP;

Assignee:

NIPPI, INCORPORATED, Tokyo, JP;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

James H Alstrum Acevedo

Assistant Examiner:

Tara Martinez

Int. Cl.
CPC ...
C07K 7/06 (2006.01); C07K 5/10 (2006.01); C07K 5/06 (2006.01); C07K 5/08 (2006.01); C07K 5/062 (2006.01); C07K 5/083 (2006.01); C07K 5/103 (2006.01); C07K 5/065 (2006.01); C07K 5/078 (2006.01); C07K 5/097 (2006.01); C07K 14/81 (2006.01); C12N 9/48 (2006.01); C07K 14/78 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); C07K 5/06 (2013.01); C07K 5/06026 (2013.01); C07K 5/06043 (2013.01); C07K 5/06078 (2013.01); C07K 5/06165 (2013.01); C07K 5/08 (2013.01); C07K 5/0806 (2013.01); C07K 5/0808 (2013.01); C07K 5/0823 (2013.01); C07K 5/10 (2013.01); C07K 5/1008 (2013.01); C07K 14/78 (2013.01); C07K 14/8103 (2013.01); C12N 9/485 (2013.01); C12Y 304/14005 (2013.01); A61K 38/00 (2013.01);
Abstract

A DPP-4 inhibitor comprising a peptide represented by the formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (SEQ ID NO: 16) (wherein Xe is an amino acid residue with an isoelectric point of 5.9 to 6.3; Pro/Ala/Hyp represents Pro, Ala, or Hyp; Xa is an amino acid residue other than Hyp, Pro, and Arg, or deletion; 5 Xb is Gly, Pro, or deletion; Xc is Pro, Ala, or deletion; and Xd is an amino acid residue or deletion) as an active component. The inhibitor can be expected to bring out an effect of lowering blood glucose levels by enhancing effects of incretins; and the inhibitor may be used as a therapeutic agent for diabetes and, in addition, can act on the immune system or the like to be thus used in 10 treatment for skin diseases or the like.

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