The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2016

Filed:

Jul. 13, 2012
Applicants:

Donald T. Moir, Concord, MA (US);

Daniel Aiello, Worcester, MA (US);

Norton P. Peet, North Andover, MA (US);

John D. Williams, Watertown, MA (US);

Matthew Torhan, Ayer, MA (US);

Inventors:

Donald T. Moir, Concord, MA (US);

Daniel Aiello, Worcester, MA (US);

Norton P. Peet, North Andover, MA (US);

John D. Williams, Watertown, MA (US);

Matthew Torhan, Ayer, MA (US);

Assignee:

MICROBIOTIX, INC., Worcester, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/00 (2006.01); A61K 31/44 (2006.01); C07D 491/056 (2006.01); A61K 31/443 (2006.01); A61K 31/381 (2006.01); A61K 31/53 (2006.01); A61K 31/165 (2006.01); A61K 31/36 (2006.01); A61K 31/4355 (2006.01); A61K 45/06 (2006.01); C07C 235/34 (2006.01); C07D 317/50 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 491/056 (2013.01); A61K 31/165 (2013.01); A61K 31/36 (2013.01); A61K 31/381 (2013.01); A61K 31/4355 (2013.01); A61K 31/443 (2013.01); A61K 31/53 (2013.01); A61K 45/06 (2013.01); C07C 235/34 (2013.01); C07D 317/50 (2013.01); C07D 405/12 (2013.01);
Abstract

Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such asspp.,spp.,spp., en tero pathogenic and enteroinvasivecoli, andspp. having such type III secretion systems.


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