The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Jan. 30, 2015
Applicant:
Brock University, St. Catharines, Ontario, CA;
Inventors:
Tomas Hudlicky, St. Catharines, CA;
Robert James Carroll, Herts, GB;
Hannes Leisch, Unterach am Attersee, AT;
Ales Machara, Brenov, CZ;
Lukas Werner, Kadan, CZ;
Mary Ann Endoma-Arias, Quezon, PH;
Assignee:
Brock University, St. Catharines, Ontario, CA;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); C07D 471/00 (2006.01); C07D 489/12 (2006.01); C07D 491/00 (2006.01); C07D 498/00 (2006.01); C07D 513/00 (2006.01); C07D 515/00 (2006.01); C07D 489/00 (2006.01); C07D 221/22 (2006.01); C07D 451/06 (2006.01); C07D 489/02 (2006.01); C07D 489/08 (2006.01);
U.S. Cl.
CPC ...
C07D 489/12 (2013.01); C07D 221/22 (2013.01); C07D 451/06 (2013.01); C07D 489/02 (2013.01); C07D 489/08 (2013.01);
Abstract
The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a transition metal catalyst in air or in the presence of an oxidant.