The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Jan. 17, 2014
Ustav Organicke Chemie a Biochemie Akademie Ved Cr, V.v.i., Prague, CZ;
Filip Teply, Roztoky u Prahy, CZ;
Miroslav Hajek, Prague, CZ;
Abstract
The invention provides helquat derivatives of general formula I, wherein substituents Rand Rare independently selected from a group comprising H and Cto Calkyl; up to three of S, S, Sand Sare present, each of S, S, Sand Sindependently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms; one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4′ are substituted with a substituent Rof general formula II or general formula III wherein Ris substituted or unsubstituted aryl; Tand Tindependently represent a bivalent hydrocarbon chain having 2-5 carbon atoms; and anions (X)and (X)independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.