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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9340539 B1

PDFFull Text
Date of Patent:
May. 17, 2016

Filed:

Aug. 22, 2012

Hepatitis c inhibitor compounds

Applicants:

Christian Brochu, Blainville, CA;

Chantal Grand-maitre, Boisbriand, CA;

Lee Fader, New Milford, CT (US);

Cyrille Kuhn, Ridgefield, CT (US);

Megan Bertrand-laperle, Laval, CA;

Marc Pesant, St. Colomban, CA;

Inventors:

Christian Brochu, Blainville, CA;

Chantal Grand-Maitre, Boisbriand, CA;

Lee Fader, New Milford, CT (US);

Cyrille Kuhn, Ridgefield, CT (US);

Megan Bertrand-Laperle, Laval, CA;

Marc Pesant, St. Colomban, CA;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:

Michael P. Morris

Edward S. Lazer

Primary Examiner:

Erich A Lesser

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 45/06 (2006.01); A61K 31/403 (2006.01); C07D 471/04 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 417/14 (2006.01); C07D 491/107 (2006.01); A61K 31/4155 (2006.01); A61K 31/4178 (2006.01); A61K 31/4196 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/403 (2013.01); A61K 31/4155 (2013.01); A61K 31/4178 (2013.01); A61K 31/4196 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); C07D 491/107 (2013.01);
Abstract

A compound of formula (I) useful for the treatment or prevention of hepatitis C viral infection, (Formula (I)) wherein: Xand Xare each independently CRor N; Ris H, (C)alkyl, (C)haloalkyl, halo. —O—(C)alkyl, NH, NH(C)alkyl or N((C)alkyl); Rand Rare each independently (C)alkyl optionally mono- or di-substituted with —O—(C)alkyl, NH, NH(C)alkyl or N((C)alkyl); or Rand R, together with the carbon to which they are attached, are linked to form a (C)cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with —(C)alkyl; Ris —C(═O)N(R)(R), —C(═O)O(R), heterocyclyl or heteroaryl, wherein each said heterocyclyl and heteroaryl is optionally substituted 1 to 3 times with R; Rand Rare each independently H or (C)alkyl optionally mono- or di-substituted with —O—(C)alkyl, NH, NH(C)alkyl or N((C)alkyl); or Rand R, together with the carbon to which they are attached, are linked to form a (C)cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with —(C)alkyl; and n is 0, 1 or 2.

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