The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Sep. 26, 2012
Aicuris Gmbh & Co. KG, Wuppertal, DE;
Wilfried Schwab, Werder, DE;
Alexander Birkmann, Wuppertal, DE;
Kurt Vogtli, Oberhofen, CH;
Dieter Haag, Ramlinsburg, CH;
Andreas Lender, Wuppertal, DE;
Alfons Grunenberg, Dormagen, DE;
Birgit Keil, Dusseldorf, DE;
Joachim Rehse, Leichlingen, DE;
AICURIS GMBH & CO. KG, Wuppertal, DE;
Abstract
The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.