The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Feb. 27, 2013
Merck, Sharp & Dohme Corp.;
Mihir Mandal, Westfield, NJ (US);
Timothy A. Blizzard, Princeton, NJ (US);
Helen Chen, Marlboro, NJ (US);
Harry Chobanian, Aberdeen, NJ (US);
Yan Guo, Westfield, NJ (US);
Barbara Pio, West Orange, NJ (US);
Zhicai Wu, Montvale, NJ (US);
Tesfaye Biftu, Freehold, NJ (US);
William J. Greenlee, Teaneck, NJ (US);
Johnny Zhaoning Zhu, Slough, GB;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: X is —O—, —N(R), —C(R)(R) or —C(O)—; and Y is —O—, —N(R), —C(R)(R) or —C(O)— and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ACS, secondary prevention of myocardial infarction or stroke, or PAD.