The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
Jul. 14, 2011
Cristianne Johanna Ferdinand Rijcken, Utrecht, NL;
Wilhelmus Everhardus Hennink, Utrecht, NL;
Cornelis Franciscus Van Nostrum, Utrecht, NL;
Isil Altintas, Utrecht, NL;
Steffen Van Der Wal, Utrecht, NL;
Robertus Matthias Joseph Liskamp, Utrecht, NL;
Johannes Anna Wilhelmus Kruijtzer, Utrecht, NL;
Cristianne Johanna Ferdinand Rijcken, Utrecht, NL;
Wilhelmus Everhardus Hennink, Utrecht, NL;
Cornelis Franciscus van Nostrum, Utrecht, NL;
Isil Altintas, Utrecht, NL;
Steffen van der Wal, Utrecht, NL;
Robertus Matthias Joseph Liskamp, Utrecht, NL;
Johannes Anna Wilhelmus Kruijtzer, Utrecht, NL;
CRISTAL DELIVERY B.V., Utrecht, NL;
Abstract
The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesizing these linkers and preparing such controlled release systems.