The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2016
Filed:
May. 27, 2010
Hyon El Choy, Seoul, KR;
Jung-joon Min, Gwaangju, KR;
Hyung Seok Kim, Gwangju, KR;
Yeongjin Hong, Gwangju, KR;
Hyon El Choy, Seoul, KR;
Jung-Joon Min, Gwaangju, KR;
Hyung Seok Kim, Gwangju, KR;
Yeongjin Hong, Gwangju, KR;
INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERISTY, Gwangju, KR;
Abstract
The present invention relates to bacteria which specifically target infarcted tissue and use thereof. The present invention provides a selective infarcted tissue-targeting bacterium for the first time, and can be used in selectively delivering drugs to the infarcted tissue or in selectively imaging the infarcted tissue. The infarcted tissue-targeting bacterium of the present invention can finish treatments by using antibiotics, and therefore, have remarkable advantages as compared to gene therapy using recombinant viruses. The infarcted tissue-targeting bacterium of the present invention have a significantly high affinity and specificity to infarcted myocardium or infarcted brain, thereby significantly reducing undesired transfections in the organs or tissues other than the heart. The gene expression by the infarcted tissue-targeting bacterium of the present invention in infarcted myocardium or infarcted brain is remotely controllable.