The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 10, 2016

Filed:

Apr. 11, 2014
Applicants:

Incyte Corporation, Wilmington, DE (US);

Incyte Holdings Corporation, Wilmington, DE (US);

Inventors:

James D Rodgers, Landenberg, PA (US);

Stacey Shepard, Wilmington, DE (US);

Argyrios G Arvanitis, Kennett Square, PA (US);

Haisheng Wang, Hockessin, DE (US);

Louis Storace, Middletown, DE (US);

Beverly Folmer, Hockessin, DE (US);

Wenyu Zhu, Media, PA (US);

Joseph Glenn, Mount Royal, NJ (US);

Lixin Shao, Newark, DE (US);

Assignees:

Incyte Holdings Corporation, Wilmington, DE (US);

Incyte Corporation, Wilmington, DE (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/90 (2006.01); A61K 31/519 (2006.01); C07D 487/00 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); C07D 471/04 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 471/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.


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